113243-00-8
113243-00-8
Chemical Structure
L-657926
- CAS No.: 113243-00-8
- Formula:C21H19ClFNO2
- Molecular Weight:371.83
InChIKey: LHJWQVJJSYPRIX-AWEZNQCLSA-N
SMILES: FC1=CC=C(N(C2=C3CCC[C@H]2CC(O)=O)CC4=CC=C(C=C4)Cl)C3=C1
Biological Activity: L-657926 is a stereoselective antagonist of the thromboxane A2 (TxA2) receptor, composed of (-)-9-chlorobenzyl-6-fluoro-1,2,3,4-tetrahydrocarbazol-1-yl acetic acid and (+)-9-chlorobenzyl-6-fluoro-1,2,3,4-tetrahydrocarbazol-l-yl acetic acid. The IC50s of (-) and (+) configurations for TxA2 are 0.27 nM and 124 nM, respectively.
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L-657926 | L-657926 is a stereoselective antagonist of the thromboxane A2 (TxA2) receptor, composed of (-)-9-chlorobenzyl-6-fluoro-1,2,3,4-tetrahydrocarbazol-1-yl acetic acid and (+)-9-chlorobenzyl-6-fluoro-1,2,3,4-tetrahydrocarbazol-l-yl acetic acid. The IC50s of (-) and (+) configurations for TxA2 are 0.27 nM and 124 nM, respectively. | |||||||||||||||||||||
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Keywords
