113302-01-5
Chemical Structure
KW-5805
- CAS No.: 113302-01-5
- Formula:C19H28Cl3N3O
- Molecular Weight:420.80
IUPAC Name: N1-(5,11-dihydrobenzo[6,7]oxepino[3,4-b]pyridin-5-yl)-N2,N2-diethylethane-1,2-diamine trihydrochloride
InChIKey: IXGYBSQLXMSBBH-UHFFFAOYSA-N
SMILES: CCN(CC)CCNC1C2=CC=CC=C2OCC3=NC=CC=C31.[H]Cl.[H]Cl.[H]Cl
Biological Activity: KW-5805 is an orally effective anti-ulcer agent that potently inhibits gastric injury induced by various necrotizing agents. KW-5805 enhances the activity of gastric mucosal glucosamine synthetase, increases the levels of gastric adherent mucus and mucosal glycoproteins, and promotes the biosynthesis, storage and secretion of gastric mucus. KW-5805 inhibits the reduction of gastric mucosal blood volume and oxygen supply caused by hemorrhagic shock. KW-5805 suppresses the development of experimental gastric and duodenal ulcers, necrotizing agent-induced gastric mucosal injury, and induced gastric acid secretion. KW-5805 can be used in ulcer-related research[1][2].
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KW-5805 | KW-5805 is an orally effective anti-ulcer agent that potently inhibits gastric injury induced by various necrotizing agents. KW-5805 enhances the activity of gastric mucosal glucosamine synthetase, increases the levels of gastric adherent mucus and mucosal glycoproteins, and promotes the biosynthesis, storage and secretion of gastric mucus. KW-5805 inhibits the reduction of gastric mucosal blood volume and oxygen supply caused by hemorrhagic shock. KW-5805 suppresses the development of experimental gastric and duodenal ulcers, necrotizing agent-induced gastric mucosal injury, and induced gastric acid secretion. KW-5805 can be used in ulcer-related research. | |||||||||||||||||||||
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- [1]. Tanaka H, Kosaka N, Tomaru A, et al.. Augmentation of the gastric mucosal defense mechanism induced by KW-5805, a novel antiulcer agent. Scandinavian journal of gastroenterology. Supplement. 1989;162:170-3. [Content Brief]
- [2]. Kosaka N, Tanaka H, Tomaru A, et al.. Effects of KW-5805, a new antiulcer agent, on experimental gastric and duodenal ulcers, gastric mucosal lesions by necrotizing agents and gastric acid secretion. Japanese journal of pharmacology. 1994 Aug;65(4):305-12. [Content Brief]
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