113579-07-0
Chemical Structure
Netzahualcoyonol
- CAS No.: 113579-07-0
- Formula:C30H38O5
- Molecular Weight:478.62
IUPAC Name: methyl (2R,3R,4aS,12bR,14aS,14bS)-3,10-dihydroxy-2,4a,6,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,11,12b,13,14,14a,14b-dodecahydropicene-2-carboxylate
InChIKey: AKILTDMBUDIAST-SMVJIKPISA-N
SMILES: O[C@@H]1C[C@](C)(CC(C)=C2[C@]3(CC[C@](C4=CC5=O)(C2=CC=C4C(C)=C5O)C)C)[C@@H]3C[C@]1(C(OC)=O)C
Biological Activity: Netzahualcoyonol is a quinone methyl triterpene isolated from the roots of Salacia multiflora (Lam.) DC. Netzahualcoyonol exhibits antibacterial and anti-biofilm activities. Netzahualcoyonol inhibits Gram-positive bacteria (MIC=3.26–52 μM). Additionally, Netzahualcoyonol demonstrates cytotoxicity against Hep G2 cells (IC50 = 1.95 μM) but exhibits low toxicity towards Vero cells[1][2].
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Netzahualcoyonol | Netzahualcoyonol is a quinone methyl triterpene isolated from the roots of Salacia multiflora (Lam.) DC. Netzahualcoyonol exhibits antibacterial and anti-biofilm activities. Netzahualcoyonol inhibits Gram-positive bacteria (MIC=3.26–52 μM). Additionally, Netzahualcoyonol demonstrates cytotoxicity against Hep G2 cells (IC50 = 1.95 μM) but exhibits low toxicity towards Vero cells. | |||||||||||||||||||||
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- [1]. Setzer W N, et al. Isolation and frontier molecular orbital investigation of bioactive quinone-methide triterpenoids from the bark of Salacia petenensis[J]. Planta Medica, 2001, 67(01): 65-69. [Content Brief]
- [2]. da Cruz Nizer W S, et al. Netzahualcoyonol from Salacia multiflora (Lam.) DC.(Celastraceae) roots as a bioactive compound against gram-positive pathogens[J]. Natural Product Research, 2022, 36(22): 5904-5909. [Content Brief]
Keywords
