1140483-31-3
Chemical Structure
A17 peptide
- CAS No.: 1140483-31-3
- Formula:C76H105N19O20S
- Molecular Weight:1636.83
InChIKey: RISOYYKHYVROCD-DUMBCNOCSA-N
SMILES: O=C(N[C@@H](CS)C(N[C@@H](C)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](CO)C(N3[C@@H](CCC3)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC4=CNC=N4)C(N[C@@H](CCCCN)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC5=CC=CC=C5)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC6=CC=C(C=C6)O)N
Biological Activity: A17 peptide is a Hsp70-targeting peptide. A17 peptide binds to the ATP-binding domains of Hsp70. A17 peptide specifically inhibits the chaperone activity, thereby increasing the cells' sensitivity to apoptosis induced by chemotherapeutic agents, such as Cisplatin (HY-17394). A17 peptide can be used for anticancer chemotherapy research, such multiple myeloma[1].
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A17 peptide | A17 peptide is a Hsp70-targeting peptide. A17 peptide binds to the ATP-binding domains of Hsp70. A17 peptide specifically inhibits the chaperone activity, thereby increasing the cells' sensitivity to apoptosis induced by chemotherapeutic agents, such as Cisplatin (HY-17394). A17 peptide can be used for anticancer chemotherapy research, such multiple myeloma. | |||||||||||||||||||||
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