1140907-13-6
1140907-13-6
Chemical Structure
Febuxostat sodium
Synonym(s): TEI 6720 sodium; TMX 67 sodium
- CAS No.: 1140907-13-6
- Formula:C16H15N2NaO3S
- Molecular Weight:338.36
IUPAC Name: sodium 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
InChIKey: CNBCRDKBNDTWPM-UHFFFAOYSA-M
SMILES: O=C(C1=C(C)N=C(C2=CC=C(OCC(C)C)C(C#N)=C2)S1)O[Na]
Biological Activity: Febuxostat (TEI 6720) sodium is a potent, selective and non-purine xanthine oxidase (XO) inhibitor with a Ki value of 0.6 nM. Febuxostat sodium has the potential for the research of hyperuricemia and gout[1][2][3].
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Febuxostat sodium | Febuxostat (TEI 6720) sodium is a potent, selective and non-purine xanthine oxidase (XO) inhibitor with a Ki value of 0.6 nM. Febuxostat sodium has the potential for the research of hyperuricemia and gout. | |||||||||||||||||||||
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References
- [1]. Takano Y, et al. Selectivity of febuxostat, a novel non-purine inhibitor of xanthine oxidase/xanthine dehydrogenase. Life Sci, 2005, 76(16), 1835-1847. [Content Brief]
- [2]. Sanchez-Lozada LG, et al. Effects of febuxostat on metabolic and renal alterations in rats with fructose-induced metabolic syndrome. Am J Physiol Renal Physiol, 2008, 294(4), F710-F718. [Content Brief]
- [3]. Sanchez-Lozada LG, et al. Effect of febuxostat on the progression of renal disease in 5/6 nephrectomy rats with and without hyperuricemia. Nephron Physiol, 2008, 108(4), p69-p78. [Content Brief]
