1147-23-5
Chemical Structure
5-Iodo-cytidine
Synonym(s): 5-Iodo-D-cytidine
- CAS No.: 1147-23-5
- Formula:C9H12IN3O5
- Molecular Weight:369.11
IUPAC Name: 4-amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-iodopyrimidin-2(1H)-one
InChIKey: LQQGJDJXUSAEMZ-UAKXSSHOSA-N
SMILES: O=C(N=C(N)C(I)=C1)N1[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O
Biological Activity: 5-Iodo-cytidine (5-Iodo-D-cytidine) is a purine nucleoside analog that acts as an intermediate in organic synthesis. 5-Iodo-cytidine serves as a chemically modified nucleotide to replace partial cytidine residues in in vitro transcription, enhancing the translation efficiency and stability of chemically modified mRNA. Purine nucleoside analogs exhibit broad anti-tumor activity and target indolent lymphoid malignancies. 5-Iodo-cytidine can be used in mRNA therapy and tumor-related research[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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5-Iodo-cytidine | 99.89% | 5-Iodo-cytidine (5-Iodo-D-cytidine) is a purine nucleoside analog that acts as an intermediate in organic synthesis. 5-Iodo-cytidine serves as a chemically modified nucleotide to replace partial cytidine residues in in vitro transcription, enhancing the translation efficiency and stability of chemically modified mRNA. Purine nucleoside analogs exhibit broad anti-tumor activity and target indolent lymphoid malignancies. 5-Iodo-cytidine can be used in mRNA therapy and tumor-related research. | ||||||||||||||||||||
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References
- [1]. Robak T, et al. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Current pharmaceutical design. 2012;18(23):3373-88. [Content Brief]
- [2]. Rohloff JC, et al. Practical synthesis of cytidine-5-carboxamide-modified nucleotide reagents. Nucleosides, nucleotides & nucleic acids. 2015;34(3):180-98. [Content Brief]
- [3]. Zhang W, et al. An Improved, Chemically Modified RNA Encoding BMP-2 Enhances Osteogenesis In Vitro and In Vivo. Tissue engineering. Part A. 2019 Jan;25(1-2):131-144. [Content Brief]
