115308-98-0
115308-98-0
Chemical Structure
Tallimustine
Synonym(s): FCE 24517
- CAS No.: 115308-98-0
- Formula:C32H38Cl2N10O4
- Molecular Weight:697.61
IUPAC Name: N-(3-amino-3-iminopropyl)-4-(4-(4-(4-(bis(2-chloroethyl)amino)benzamido)-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-pyrrole-2-carboxamide
InChIKey: ARKYUICTMUZVEW-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(N(CCCl)CCCl)C=C1)NC2=CN(C)C(C(NC3=CN(C)C(C(NC4=CN(C)C(C(NCCC(N)=N)=O)=C4)=O)=C3)=O)=C2
Biological Activity: Tallimustine (FCE 24517), a distamycin-A derivative, is an anticancer agent[1][2][4].
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Tallimustine | Tallimustine (FCE 24517), a distamycin-A derivative, is an anticancer agent. | |||||||||||||||||||||
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References
- [1]. Herzig MC, et al. Tallimustine lesions in cellular DNA are AT sequence-specific but not region-specific. Biochemistry. 1999 Oct 19;38(42):14045-55. [Content Brief]
- [2]. Bianchi N, et al. Accumulation of gamma-globin mRNA and induction of erythroid differentiation after treatment of human leukaemic K562 cells with tallimustine. Br J Haematol. 2001 Jun;113(4):951-61. [Content Brief]
- [4]. Tagliabue G, et al. Combination of the new minor groove alkylator tallimustine and melphalan. Eur J Cancer. 1997 Feb;33(2):284-7. [Content Brief]
Keywords
