1158983-49-3
Chemical Structure
SP94
- CAS No.: 1158983-49-3
- Formula:C65H104N14O16
- Molecular Weight:1337.61
SMILES: O=C([C@H]1N(CCC1)C([C@H]([C@H](O)C)NC([C@@H](NC([C@H]([C@@H](C)CC)NC([C@H]([C@@H](C)CC)NC([C@H](CO)NC([C@@H](NC([C@@H](N)CO)=O)CC2=CC=CC=C2)=O)=O)=O)=O)CC3=CN=CN3)=O)=O)N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(N4[C@@H](CCC4)C(N[C@H](C(O)=O)CC(C)C)=O)=O)=O
Biological Activity: SP94 is a peptide ligand with high specificity for hepatocellular carcinoma cells. SP94 selectively binds to multiple hepatocellular carcinoma cell lines in vitro. SP94 inhibits tumor growth in a mouse model of hepatocellular carcinoma by promoting apoptosis and reducing angiogenesis. SP94 can be used as a specific probe for hepatocellular carcinoma imaging. SP94 is useful for hepatocellular carcinoma research[1][2][3].
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SP94 | SP94 is a peptide ligand with high specificity for hepatocellular carcinoma cells. SP94 selectively binds to multiple hepatocellular carcinoma cell lines in vitro. SP94 inhibits tumor growth in a mouse model of hepatocellular carcinoma by promoting apoptosis and reducing angiogenesis. SP94 can be used as a specific probe for hepatocellular carcinoma imaging. SP94 is useful for hepatocellular carcinoma research. | |||||||||||||||||||||
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References
- [1]. Lo A, et al. Hepatocellular carcinoma cell-specific peptide ligand for targeted drug delivery. Mol Cancer Ther. 2008 Mar;7(3):579-89. [Content Brief]
- [2]. Toita R, et al. Development of human hepatocellular carcinoma cell-targeted protein cages. Bioconjug Chem. 2012 Jul 18;23(7):1494-501. [Content Brief]
