1166-34-3
1166-34-3
Chemical Structure
Cinanserin
- CAS No.: 1166-34-3
- Formula:C20H24N2OS
- Molecular Weight:340.48
IUPAC Name: N-(2-((3-(dimethylamino)propyl)thio)phenyl)cinnamamide
InChIKey: RSUVYMGADVXGOU-BUHFOSPRSA-N
SMILES: O=C(NC1=CC=CC=C1SCCCN(C)C)/C=C/C2=CC=CC=C2
Biological Activity: Cinanserin (SQ 10643) is a potent and selective 5-HT2 antagonist with Ki values of 41, 3500 nM for 5-HT2, 5-HT1, respectively. Cinanserin also is a SARS-CoV 3CLpro inhibitor with an KD value of 49.4, 18.2 µM for SARS-CoV 3CLpro, HCoV-229E 3CLpro, respectively. Cinanserin reduces systemic burn edema levels[1][2][3].
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Cinanserin | Cinanserin (SQ 10643) is a potent and selective 5-HT2 antagonist with Ki values of 41, 3500 nM for 5-HT2, 5-HT1, respectively. Cinanserin also is a SARS-CoV 3CLpro inhibitor with an KD value of 49.4, 18.2 µM for SARS-CoV 3CLpro, HCoV-229E 3CLpro, respectively. Cinanserin reduces systemic burn edema levels. | |||||||||||||||||||||
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References
- [1]. Hernekamp JF, et al. Cinanserin reduces plasma extravasation after burn plasma transfer in rats. Burns. 2013 Sep;39(6):1226-33. [Content Brief]
- [2]. Chen L, et al. Cinanserin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro. J Virol. 2005 Jun;79(11):7095-103. [Content Brief]
- [3]. Leysen, J. E., et al. Receptor binding profile of R 41 468, A novel antagonist at 5-HT2 receptors. Life Sciences, 1981, 28(9), 1015-1022. [Content Brief]
Keywords
