116679-70-0
Chemical Structure
UC-773587
- CAS No.: 116679-70-0
- Formula:C28H15O5-
- Molecular Weight:431.42
IUPAC Name: 2-(11-hydroxy-3-oxo-3H-dibenzo[c,h]xanthen-7-yl)benzoate
InChIKey: LFZLBQHTPRXHSQ-UHFFFAOYSA-M
SMILES: OC(C=CC1=C2O3)=CC1=CC=C2C(C4=CC=CC=C4C([O-])=O)=C5C3=C6C=CC(C=C6C=C5)=O
Biological Activity: UC-773587 is a selective SOS1 catalytic activity inhibitor. UC-773587 binds to the catalytic site of Sos1 over HRas and ITSN (a RhoGEF) and inhibits nucleotide exchange with an IC50 value of 4.5 μM. UC-773587 mappes to the Ras switch II interaction region of the Sos1 catalytic site. UC-773587 can be used for the study of prostate cancer[1][2].
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UC-773587 | UC-773587 is a selective SOS1 catalytic activity inhibitor. UC-773587 binds to the catalytic site of Sos1 over HRas and ITSN (a RhoGEF) and inhibits nucleotide exchange with an IC50 value of 4.5 μM. UC-773587 mappes to the Ras switch II interaction region of the Sos1 catalytic site. UC-773587 can be used for the study of prostate cancer. | |||||||||||||||||||||
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- [1]. Gray JL, et al. Targeting the Small GTPase Superfamily through Their Regulatory Proteins. Angew Chem Int Ed Engl. 2020 Apr 16;59(16):6342-6366. [Content Brief]
- [2]. Evelyn CR, et al. Combined rational design and a high throughput screening platform for identifying chemical inhibitors of a Ras-activating enzyme. J Biol Chem. 2015 May 15;290(20):12879-98. [Content Brief]
Keywords
