1173435-64-7
1173435-64-7
Chemical Structure
BMS-665053
- CAS No.: 1173435-64-7
- Formula:C16H14Cl3F2N3O2
- Molecular Weight:424.66
IUPAC Name: (S)-5-chloro-1-(1-cyclopropylethyl)-3-((2,6-dichloro-4-(difluoromethoxy)phenyl)amino)pyrazin-2(1H)-one
InChIKey: NFRNVFLIULAQST-ZETCQYMHSA-N
SMILES: ClC1=CN([C@H](C2CC2)C)C(C(NC3=C(Cl)C=C(OC(F)F)C=C3Cl)=N1)=O
Biological Activity: BMS-665053 is a corticotropin-releasing factor-1 (CRF1) receptor antagonist (IC50 = 1.0 nM). BMS-665053)11 is a potent inhibitor of CRF-stimulated cyclic adenosine monophosphate (cAMP) production in human Y-79 retinoblastoma cells (IC50 = 4.9 nM)[1].
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BMS-665053 | BMS-665053 is a corticotropin-releasing factor-1 (CRF1) receptor antagonist (IC50 = 1.0 nM). BMS-665053)11 is a potent inhibitor of CRF-stimulated cyclic adenosine monophosphate (cAMP) production in human Y-79 retinoblastoma cells (IC50 = 4.9 nM). | |||||||||||||||||||||
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