1175017-90-9
Chemical Structure
AKN-028
- CAS No.: 1175017-90-9
- Formula:C17H14N6
- Molecular Weight:302.33
IUPAC Name: N2-(1H-indol-5-yl)-6-(pyridin-4-yl)pyrazine-2,3-diamine
InChIKey: JLRIJKVMMZEKDF-UHFFFAOYSA-N
SMILES: NC1=NC=C(N=C1NC2=CC3=C(C=C2)NC=C3)C4=CC=NC=C4
Biological Activity: AKN-028, a novel tyrosine kinase (TK) inhibitor, is a potent, orally active FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor with an IC50 value of 6 nM. AKN-028 inhibits FLT3 autophosphorylation. AKN-028 induces dose-dependent cytotoxic response (mean IC50=1 μM). AKN-028 induces apoptosisby activation of caspase 3. AKN-028 can be used in research of acute myeloid leukemia (AML)[1].
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AKN-028 | 99.72% | AKN-028, a novel tyrosine kinase (TK) inhibitor, is a potent, orally active FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor with an IC50 value of 6 nM. AKN-028 inhibits FLT3 autophosphorylation. AKN-028 induces dose-dependent cytotoxic response (mean IC50=1 μM). AKN-028 induces apoptosisby activation of caspase 3. AKN-028 can be used in research of acute myeloid leukemia (AML). | ||||||||||||||||||||
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Keywords
