118290-26-9
118290-26-9
Chemical Structure
AF-DX 384
- CAS. Nr.: 118290-26-9
- Formula:C27H38N6O2
- Molecular Weight:478.63
IUPAC Name: N-(2-(2-((dipropylamino)methyl)piperidin-1-yl)ethyl)-6-oxo-5,6-dihydro-11H-benzo[e]pyrido[3,2-b][1,4]diazepine-11-carboxamide
InChIKey: MZDYABXXPZNUCT-UHFFFAOYSA-N
SMILES: O=C1NC2=CC=CN=C2N(C3=C1C=CC=C3)C(NCCN4CCCCC4CN(CCC)CCC)=O
Biological Activity: AF-DX 384 is a selective antagonist of M2 and M4 muscarinic acetylcholine receptors (Kis=6.03 and 10 nM, respectively)[1]. AF-DX 384 reverses deficits in novel object recognition and passive avoidance in aged rats, as well as in young rats with impairments induced by scopolamine[2].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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AF-DX 384 | 98.0% | AF-DX 384 is a selective antagonist of M2 and M4 muscarinic acetylcholine receptors (Kis=6.03 and 10 nM, respectively). AF-DX 384 reverses deficits in novel object recognition and passive avoidance in aged rats, as well as in young rats with impairments induced by scopolamine. | ||||||||||||||||||||
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References
- [1]. Dörje F, et al. Antagonist binding profiles of five cloned human muscarinic receptor subtypes. J Pharmacol Exp Ther. 1991 Feb;256(2):727-33. [Content Brief]
- [2]. Vannucchi MG, et al. Selective muscarinic antagonists differentially affect in vivo acetylcholine release and memory performances of young and aged rats. Neuroscience. 1997 Aug;79(3):837-46. [Content Brief]
