118314-35-5
118314-35-5
Chemical Structure
DS 4574
- CAS No.: 118314-35-5
- Formula:C13H16N6OS
- Molecular Weight:304.37
IUPAC Name: 6-(2-cyclohexylethyl)-[1,3,4]thiadiazolo[3,2-a][1,2,3]triazolo[4,5-d]pyrimidin-9(1H)-one
InChIKey: ASIFEXZWAKYMRM-UHFFFAOYSA-N
SMILES: O=C1C2=C(N=C3SC(CCC4CCCCC4)=NN13)N=NN2
Biological Activity: DS 4574 is an orally active peptidoleukotriene receptor antagonist and mast cell stabilizer. DS 4574 has antiulcer, gastroprotective and antisecretory effects. DS 4574 inhibits various types of experimental asthma models. DS 4574 protects rats from endotoxin-induced intestinal injury[1][2][3].
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DS 4574 | DS 4574 is an orally active peptidoleukotriene receptor antagonist and mast cell stabilizer. DS 4574 has antiulcer, gastroprotective and antisecretory effects. DS 4574 inhibits various types of experimental asthma models. DS 4574 protects rats from endotoxin-induced intestinal injury. | |||||||||||||||||||||
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References
- [1]. Tabuchi Y, et al. Protective effect of DS-4574, a peptidoleukotriene receptor antagonist, against endotoxin-induced intestinal injury in rats. Eur J Pharmacol. 1995 Feb 6;273(3):281-4. [Content Brief]
- [2]. Yamashika Y, et al. Antisecretory effect of DS-4574, a mast cell stabilizer with peptidoleukotriene antagonism, on gastric acid secretion in the pig. Agents Actions. 1994 Mar;41(1-2):17-20. [Content Brief]
- [3]. Tabuchi Y, et al. Effect of DS-4574, a novel peptidoleukotriene antagonist with mast cell stabilizing action, on acute gastric lesions and gastric secretion in rats. Jpn J Pharmacol. 1992 Dec;60(4):335-40. [Content Brief]
Keywords
