1185036-77-4
Chemical Structure
IPS-05002
- CAS No.: 1185036-77-4
- Formula:C22H19FN4O2S
- Molecular Weight:422.48
IUPAC Name: 3-(4-fluorobenzyl)-6-hydroxy-5-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
InChIKey: ZJHUDWNYBZVQFU-UHFFFAOYSA-N
SMILES: OC1=C(C2NCCC3=C2NC4=CC=CC=C43)C(N(C(N1)=S)CC5=CC=C(C=C5)F)=O
Biological Activity: IPS-05002 is an α5β1 antagonist. IPS-05002 can inhibit VEGF-stimulated human umbilical vein endothelial cell (HUVEC) proliferation, adhesion, and migration, and also suppresses tubular network formation. IPS-05002 can upregulate IKB-β, XRCC4, and downregulate Cdc6 in VEGF-induced HUVECs. IPS-05002 can be used for the study of tumor angiogenesis[1].
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IPS-05002 | IPS-05002 is an α5β1 antagonist. IPS-05002 can inhibit VEGF-stimulated human umbilical vein endothelial cell (HUVEC) proliferation, adhesion, and migration, and also suppresses tubular network formation. IPS-05002 can upregulate IKB-β, XRCC4, and downregulate Cdc6 in VEGF-induced HUVECs. IPS-05002 can be used for the study of tumor angiogenesis. | |||||||||||||||||||||
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