118573-60-7
Chemical Structure
CBDMB
Synonym(s): 5-N-(4-Chlorobenzyl)-2',4'-dimethylbenzamil
- CAS No.: 118573-60-7
- Formula:C22H23Cl2N7O
- Molecular Weight:472.37
IUPAC Name: 3-amino-6-chloro-5-((4-chlorobenzyl)amino)-N-(N-(2,4-dimethylbenzyl)carbamimidoyl)pyrazine-2-carboxamide
InChIKey: MGLQFHOCPGELNL-UHFFFAOYSA-N
SMILES: O=C(NC(=N)NCC1=CC=C(C=C1C)C)C2=NC(Cl)=C(N=C2N)NCC3=CC=C(Cl)C=C3
Biological Activity: CBDMB (5-N-(4-Chlorobenzyl)-2',4'-dimethylbenzamil) is a Na+/Ca2+ exchanger inhibitor. CBDMB blocks both forward and reverse transport and preferentially inhibits Ca2+ influx by interacting with the intracellular Na+ site. CBDMB enhances glutamate-induced neurotoxicity and delayed neuronal death. CBDMB reduces procoagulant platelet responses, Annexin V-positive phosphatidylserine-exposing platelets, and COAT formation by inhibiting reverse-mode NCX, and delays the loss of mitochondrial membrane potential and superoxide production. CBDMB can be used for research on focal cerebral ischemia[1][2][3][4][5][6][7].
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CBDMB | CBDMB (5-N-(4-Chlorobenzyl)-2',4'-dimethylbenzamil) is a Na+/Ca2+ exchanger inhibitor. CBDMB blocks both forward and reverse transport and preferentially inhibits Ca2+ influx by interacting with the intracellular Na+ site. CBDMB enhances glutamate-induced neurotoxicity and delayed neuronal death. CBDMB reduces procoagulant platelet responses, Annexin V-positive phosphatidylserine-exposing platelets, and COAT formation by inhibiting reverse-mode NCX, and delays the loss of mitochondrial membrane potential and superoxide production. CBDMB can be used for research on focal cerebral ischemia. | |||||||||||||||||||||
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References
- [1]. Andreeva N, et al. Inhibition of Na+/Ca2+ exchange enhances delayed neuronal death elicited by glutamate in cerebellar granule cell cultures. Brain research. 1991 May 10;548(1-2):322-5.
- [2]. Aliotta A, et al. High-dose epinephrine enhances platelet aggregation at the expense of procoagulant activity. Thrombosis and haemostasis. 2021 Oct;121(10):1337-44.
- [3]. Sharikabad MN, et al. Inhibition by 5-N-(4-chlorobenzyl)-2',4'-dimethylbenzamil of Na+/Ca2+ exchange and L-type Ca2+ channels in isolated cardiomyocytes. Pharmacology & toxicology. 1997 Feb;80(2):57-61.
- [4]. Hunyady LA, et al. Na+-H+ and Na+-Ca2+ exchange in glomerulosa cells: possible role in control of aldosterone production. American Journal of Physiology-Cell Physiology. 1988 Jun 1;254(6):C744-50.
- [5]. Aliotta A, et al. Sodium–calcium exchanger reverse mode sustains dichotomous ion fluxes required for procoagulant COAT platelet formation. Thrombosis and haemostasis. 2021 Mar;121(03):309-21.
- [6]. Tortiglione A, et al. Na+/Ca2+ exchanger maintains ionic homeostasis in the peri-infarct area. Stroke. 2007 May 1;38(5):1614-20.
- [7]. Roberts DE, et al. Molecular and functional characterization of the human platelet Na+/Ca2+ exchangers. British journal of pharmacology. 2012 Feb;165(4):922-36.
