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Cat. No.: HY-189044

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CBDMB

Name: CBDMB
Brand: MedChemExpress
SKU: HY-189044
Availability: PreOrder

(Synonyms: 5-N-(4-Chlorobenzyl)-2',4'-dimethylbenzamil)

CBDMB (5-N-(4-Chlorobenzyl)-2',4'-dimethylbenzamil) is a Na⁺/Ca²⁺ exchanger inhibitor. CBDMB blocks both forward and reverse transport and preferentially inhibits Ca²⁺ influx by interacting with the intracellular Na⁺ site. CBDMB enhances glutamate-induced neurotoxicity and delayed neuronal death. CBDMB reduces procoagulant platelet responses, Annexin V-positive phosphatidylserine-exposing platelets, and COAT formation by inhibiting reverse-mode NCX, and delays the loss of mitochondrial membrane potential and superoxide production. CBDMB can be used for research on focal cerebral ischemia.

For research use only. We do not sell to patients.

CAS No.: 118573-60-7
Formula: C₂₂H₂₃Cl₂N₇O
Molecular Weight:472.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

CBDMB Chemical Structure

CAS No.: 118573-60-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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Chemical Information
Purity & Documentation
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Biological Activity

Description

All Sodium Channel Isoforms :

All Calcium Channel Isoforms :

In Vitro

Cardiovascular RegulationGlutamate Release or ReceptorsMitochondrial FunctionOxidative StressRegulation of Cardiac Pump FunctionOthers

Cardiovascular Regulation

CBDMB inhibits angiotensin II-, ACTH (Adrenocorticotropic hormone) (HY-106373)-, and dibutyryl cAMP (Bucladesine) (HY-B0764B)-stimulated Aldosterone (HY-113313) production in rat adrenal zona glomerulosa cells^[4].

Glutamate Release or Receptors

CBDMB (10 μM) enhances glutamate-induced delayed neuronal death in primary rat cerebellar granule cell cultures, with 88.6% dead cells when exposed during glutamate challenge and 96.6% when exposed both during and after glutamate challenge^[1].

Mitochondrial Function

CBDMB delays and reduces the loss of mitochondrial transmembrane potential in human platelets activated by CVX plus THR^[5].

Oxidative Stress

Mitochondrial Function

CBDMB dose-dependently reduces mitochondrial superoxide generation in human platelets activated by CVX plus THR^[5].

Regulation of Cardiac Pump Function

CBDMB (15-120 min) inhibits sarcolemmal Na⁺/Ca²⁺ exchange in isolated adult rat ventricular myocytes, with an IC₅₀ of 21 μM^[3].
CBDMB (10 nM-100 μM; 15-120 min) inhibits L-type Ca²⁺ channel-mediated Ca²⁺ uptake in isolated adult rat ventricular cardiomyocytes only after prolonged preincubation, with an IC₅₀ of 4.0 μM at 120 min^[3].
CBDMB (120 min) inhibits the binding of specific (+)-[³H]isradipine to L-type Ca²⁺ channels in isolated adult rat ventricular cardiomyocytes, with an IC₅₀ of 7 μM at 120 min^[3].

Others

CBDMB (3 µM; 5 min) reduces the formation of Annexin-V-positive procoagulant COAT platelets in CVX-plus-THR-stimulated human platelets, and high-dose EPI further enhances this reduction^[2].
CBDMB (1-30 μM; 30 min) inhibits basal and Ouabain (HY-B1457)-stimulated ⁴⁵Ca influx in rat adrenal glomerulosa cells^[4].
CBDMB (0.1-100 μM) inhibits human procoagulant COAT platelet formation after CVX plus THR activation, with an IC₅₀ of 2.85 μM^[5].
CBDMB reduces overall Ca²⁺ influx in human COAT and non-COAT platelets after CVX plus THR activation, and modulates Na⁺ efflux kinetics^[5].
CBDMB enhances A23187 (Calcimycin) (HY-N6687)-induced phosphatidylserine exposure in human platelets by preventing calcium efflux, with no direct inhibitory effect on PS exposure^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 118573-60-7
Molecular Weight 472.37
Formula C₂₂H₂₃Cl₂N₇O
SMILES

O=C(NC(=N)NCC1=CC=C(C=C1C)C)C2=NC(Cl)=C(N=C2N)NCC3=CC=C(Cl)C=C3
Synonyms

5-N-(4-Chlorobenzyl)-2',4'-dimethylbenzamil
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Andreeva N, et al. Inhibition of Na+/Ca2+ exchange enhances delayed neuronal death elicited by glutamate in cerebellar granule cell cultures. Brain research. 1991 May 10;548(1-2):322-5.

[2]. Aliotta A, et al. High-dose epinephrine enhances platelet aggregation at the expense of procoagulant activity. Thrombosis and haemostasis. 2021 Oct;121(10):1337-44.

[3]. Sharikabad MN, et al. Inhibition by 5-N-(4-chlorobenzyl)-2',4'-dimethylbenzamil of Na+/Ca2+ exchange and L-type Ca2+ channels in isolated cardiomyocytes. Pharmacology & toxicology. 1997 Feb;80(2):57-61.

[4]. Hunyady LA, et al. Na+-H+ and Na+-Ca2+ exchange in glomerulosa cells: possible role in control of aldosterone production. American Journal of Physiology-Cell Physiology. 1988 Jun 1;254(6):C744-50.

[5]. Aliotta A, et al. Sodium–calcium exchanger reverse mode sustains dichotomous ion fluxes required for procoagulant COAT platelet formation. Thrombosis and haemostasis. 2021 Mar;121(03):309-21.

[6]. Tortiglione A, et al. Na+/Ca2+ exchanger maintains ionic homeostasis in the peri-infarct area. Stroke. 2007 May 1;38(5):1614-20.

[7]. Roberts DE, et al. Molecular and functional characterization of the human platelet Na+/Ca2+ exchangers. British journal of pharmacology. 2012 Feb;165(4):922-36.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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CBDMB

All Sodium Channel Isoforms

All Calcium Channel Isoforms

Biological Activity

Description

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Bioz

Keywords

Your Recently Viewed Products

CBDMB

All Sodium Channel Isoforms

All Calcium Channel Isoforms

Biological Activity

Description

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CBDMB Related Classifications

HY-189044 Related Classifications

Bioz

Keywords

Your Recently Viewed Products