1196546-33-4
1196546-33-4
Chemical Structure
GNF-8625
- CAS No.: 1196546-33-4
- Formula:C31H30FN7O
- Molecular Weight:535.61
IUPAC Name: (R)-1-(6-(6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)-[2,4'-bipyridin]-2'-yl)piperidin-4-ol
InChIKey: BLGCSOKKBWHJMB-HHHXNRCGSA-N
SMILES: FC1=CC=CC([C@@H]2N(CCC2)C3=NN4C(C5=CC=CC(C6=CC=NC(N7CCC(CC7)O)=C6)=N5)=CN=C4C=C3)=C1
Biological Activity: GNF-8625 is a broad-spectrum TRK inhibitor that can combine with Thalidomide to form a PROTAC degrader. The IC50 of GNF-8625 for inhibiting TRKA, TRKB, and TRKC are 0.8 nM, 22 nM, and 5.4 nM, respectively.
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GNF-8625 | GNF-8625 is a broad-spectrum TRK inhibitor that can combine with Thalidomide to form a PROTAC degrader. The IC50 of GNF-8625 for inhibiting TRKA, TRKB, and TRKC are 0.8 nM, 22 nM, and 5.4 nM, respectively. | |||||||||||||||||||||
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Keywords
