121588-75-8
121588-75-8
Chemical Structure
Amesergide
- CAS No.: 121588-75-8
- Formula:C25H35N3O
- Molecular Weight:393.56
IUPAC Name: (6aR,9R,10aR)-N-cyclohexyl-4-isopropyl-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide
InChIKey: KEMOOQHMCGCZKH-JMUQELJHSA-N
SMILES: CC(N1C2=C3C([C@]4([H])[C@@](N(C[C@@H](C4)C(NC5CCCCC5)=O)C)([H])CC3=C1)=CC=C2)C
Biological Activity: Amesergide is a serotonin (5-HT1C/2) antagonist. Amesergide can result in a reduction of progeny body weight gains in maternal animals. Amesergide can be studied in research on depression[1][2].
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Amesergide | Amesergide is a serotonin (5-HT1C/2) antagonist. Amesergide can result in a reduction of progeny body weight gains in maternal animals. Amesergide can be studied in research on depression. | |||||||||||||||||||||
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References
- [1]. Seyler, D. E., et al., (1993). Effects of the serotonin antagonist amesergide on reproduction in female rats. Reproductive toxicology (Elmsford, N.Y.), 7(6), 607-612. [Content Brief]
- [2]. Kelich, S. L., et al., (1995). Developmental toxicity of amesergide administered by gavage to CD rats and New Zealand white rabbits. Fundamental and applied toxicology : official journal of the Society of Toxicology, 27(2), 247-251. [Content Brief]
