1220516-48-2
Chemical Structure
JAK2-IN-24
- CAS No.: 1220516-48-2
- Formula:C16H16FN9
- Molecular Weight:353.36
IUPAC Name: (S)-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N4-(1-methyl-1H-imidazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
InChIKey: QHXBWJSQXSYAGG-VIFPVBQESA-N
SMILES: CN1C=C(NC2=C3C(NC=C3)=NC(N[C@H](C4=NC=C(F)C=N4)C)=N2)N=C1
Biological Activity: JAK2-IN-24 is an orally active JAK2 inhibitor with an IC50 < 0.003 μM. JAK2-IN-24 blocks the JAK/STAT signaling pathway. JAK2-IN-24 inhibits JAK1 and JAK3 tyrosine kinases. JAK2-IN-24 inhibits pSTAT5 levels in mouse spleen in the TEL-JAK2 implantation model. JAK2-IN-24 inhibits tumor growth. JAK2-IN-24 can be used in research on myeloproliferative neoplasms[1].
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JAK2-IN-24 | JAK2-IN-24 is an orally active JAK2 inhibitor with an IC50 < 0.003 μM. JAK2-IN-24 blocks the JAK/STAT signaling pathway. JAK2-IN-24 inhibits JAK1 and JAK3 tyrosine kinases. JAK2-IN-24 inhibits pSTAT5 levels in mouse spleen in the TEL-JAK2 implantation model. JAK2-IN-24 inhibits tumor growth. JAK2-IN-24 can be used in research on myeloproliferative neoplasms. | |||||||||||||||||||||
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