1221154-42-2
Chemical Structure
5-Methyl cromolyn disodium
Synonym(s): C5OH
- CAS No.: 1221154-42-2
- Formula:C25H18Na2O11
- Molecular Weight:540.38
IUPAC Name: sodium 5,5'-((3-hydroxypentane-1,5-diyl)bis(oxy))bis(4-oxo-4H-chromene-2-carboxylate)
InChIKey: BJZIWUVZJRREHR-UHFFFAOYSA-L
SMILES: O=C(C(OC1=CC=CC(OCCC(CCOC(C=CC=C2OC(C(O[Na])=O)=C3)=C2C3=O)O)=C14)=CC4=O)O[Na]
Biological Activity: 5-Methyl cromolyn (C5OH) disodium, an analog of Cromolyn (HY-B1619), is a S100P inhibitor. 5-Methyl cromolyn disodium inhibits the binding of S100P to its receptor RAGE, NF-κB activity and cell proliferation, and promotes Gemcitabine (HY-17026)-induced apoptosis. 5-Methyl cromolyn disodium reduces tumor growth and metastasis, and prolongs survival in mouse models of syngeneic PDAC. 5-Methyl cromolyn disodium can be used for pancreatic cancer like pancreatic ductal adenocarcinoma (PDAC) research[1].
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5-Methyl cromolyn disodium | 5-Methyl cromolyn (C5OH) disodium, an analog of Cromolyn (HY-B1619), is a S100P inhibitor. 5-Methyl cromolyn disodium inhibits the binding of S100P to its receptor RAGE, NF-κB activity and cell proliferation, and promotes Gemcitabine (HY-17026)-induced apoptosis. 5-Methyl cromolyn disodium reduces tumor growth and metastasis, and prolongs survival in mouse models of syngeneic PDAC. 5-Methyl cromolyn disodium can be used for pancreatic cancer like pancreatic ductal adenocarcinoma (PDAC) research. | |||||||||||||||||||||
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