1224925-64-7
1224925-64-7
Chemical Structure
Granisetron-d3
- CAS No.: 1224925-64-7
- Formula:C18H21D3N4O
- Molecular Weight:315.43
IUPAC Name: 1-methyl-N-((1R,3r,5S)-9-(methyl-d3)-9-azabicyclo[3.3.1]nonan-3-yl)-1H-indazole-3-carboxamide
InChIKey: MFWNKCLOYSRHCJ-GYKMACLMSA-N
SMILES: C(N[C@H]1C[C@@H]2N(C([2H])([2H])[2H])[C@H](C1)CCC2)(=O)C=3C=4C(N(C)N3)=CC=CC4
Biological Activity: Granisetron-d3 is the deuterium labeled Granisetron. Granisetron (BRL 43694) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy[1][2].
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Granisetron-d3 | Granisetron-d3 is the deuterium labeled Granisetron. Granisetron (BRL 43694) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. | |||||||||||||||||||||
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Granisetron (Standard) | ≥98% | Granisetron (Standard) is the analytical standard of Granisetron. This product is intended for research and analytical applications. Granisetron (BRL 43694) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. | ||||||||||||||||||||
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Granisetron-d4 | Granisetron-d4 (BRL 43694-d4) is deuterium labeled Granisetron. Granisetron (BRL 43694) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. | |||||||||||||||||||||
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Granisetron-d6 (Standard) | Granisetron-d6 (BRL 43694-d6) is deuterium labeled Granisetron. Granisetron (BRL 43694) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. | |||||||||||||||||||||
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Granisetron-d3 (1-methyl-d3) | Granisetron-d3 (1-methyl-d3) is the deuterium labeled Granisetron. | |||||||||||||||||||||
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Granisetron | 99.88% | Granisetron (BRL 43694) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Sanger GJ, Nelson DR. Selective and functional 5-hydroxytryptamine3 receptor antagonism by BRL 43694 (granisetron). Eur J Pharmacol. 1989 Jan 10;159(2):113-24. [Content Brief]
