1226895-20-0
1226895-20-0
Chemical Structure
Otenaproxesul
Synonym(s): ATB-346
- CAS No.: 1226895-20-0
- Formula:C21H19NO3S
- Molecular Weight:365.45
IUPAC Name: 4-carbamothioylphenyl 2-(6-methoxynaphthalen-2-yl)propanoate
InChIKey: YCNMAPLPQYQJFC-UHFFFAOYSA-N
SMILES: COC1=CC=C(C=C(C(C)C(OC2=CC=C(C(N)=S)C=C2)=O)C=C3)C3=C1
Biological Activity: Otenaproxesul (ATB-346), an orally active non-steroidal anti-inflammatory drug (NSAID), inhibits cyclooxygenase-1 and 2 (COX-1 and 2). Otenaproxesul possesses antiinflammatory and antinociceptive activities[1][4].
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Otenaproxesul | 98.69% | Otenaproxesul (ATB-346), an orally active non-steroidal anti-inflammatory drug (NSAID), inhibits cyclooxygenase-1 and 2 (COX-1 and 2). Otenaproxesul possesses antiinflammatory and antinociceptive activities. | ||||||||||||||||||||
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Otenaproxesul (Standard) | ≥98% | Otenaproxesul (Standard) is the analytical standard of Otenaproxesul. This product is intended for research and analytical applications. Otenaproxesul (ATB-346), an orally active non-steroidal anti-inflammatory drug (NSAID), inhibits cyclooxygenase-1 and 2 (COX-1 and 2). Otenaproxesul possesses antiinflammatory and antinociceptive activities. | ||||||||||||||||||||
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References
- [1]. John L Wallace, et al. Markedly reduced toxicity of a hydrogen sulphide-releasing derivative of naproxen (ATB-346). Br J Pharmacol. 2010 Mar;159(6):1236-46. [Content Brief]
- [4]. panelEduardoEkundi-Valentim, et al. P4 Antiinflammatory and antinociceptive effects of ATB-346, a gastric sparing hydrogen sulfide-releasing naproxen, in rats with carrageenan-induced knee joint synovitis. Nitric Oxide. Volume 27, Supplement 2, 15 September 2012, Page S13.
