1227156-72-0
1227156-72-0
Chemical Structure
Amelparib
Synonym(s): JPI-289 free base
- CAS No.: 1227156-72-0
- Formula:C19H25N3O3
- Molecular Weight:343.42
IUPAC Name: 10-ethoxy-8-(morpholinomethyl)-2,3,4,6-tetrahydrobenzo[h][1,6]naphthyridin-5(1H)-one
InChIKey: WBBZUHMHBSXBDT-UHFFFAOYSA-N
SMILES: O=C1C2=C(C3=C(C=C(C=C3N1)CN4CCOCC4)OCC)NCCC2
Biological Activity: Amelparib (JPI-289 free base) is a potent, orally active, and water-soluble inhibitor of PARP-1. Amelparib inhibits PARP-1 activity (IC50=18.5 nM) and cellular PAR formation (IC50=10.7 nM) in the nanomolar range. Amelparib is a potential neuroprotective agent. Amelparib has the potential for the research of acute ischaemic stroke[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Amelparib | 99.17% | Amelparib (JPI-289 free base) is a potent, orally active, and water-soluble inhibitor of PARP-1. Amelparib inhibits PARP-1 activity (IC50=18.5 nM) and cellular PAR formation (IC50=10.7 nM) in the nanomolar range. Amelparib is a potential neuroprotective agent. Amelparib has the potential for the research of acute ischaemic stroke. | ||||||||||||||||||||
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