123258-84-4
123258-84-4
Chemical Structure
Itasetron
Synonym(s): DA 6215; U98079A
- CAS. Nr.: 123258-84-4
- Formula:C16H20N4O2
- Molecular Weight:300.36
IUPAC Name: N-((1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-carboxamide
InChIKey: RWXRJSRJIITQAK-ZSBIGDGJSA-N
SMILES: O=C1N(C2=CC=CC=C2N1)C(N[C@@H]3C[C@@H]4CC[C@@H](N4C)C3)=O
Biological Activity: Itasetron (DA 6215) is a selective 5-HT3 receptor antagonist. Itasetron improves spatial learning and memory abilities in the aged rat. Itasetron has potent antiemetic properties. Itasetron is used for age-related memory degeneration in rodents[1][2].
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Itasetron | Itasetron (DA 6215) is a selective 5-HT3 receptor antagonist. Itasetron improves spatial learning and memory abilities in the aged rat. Itasetron has potent antiemetic properties. Itasetron is used for age-related memory degeneration in rodents. | |||||||||||||||||||||
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References
- [1]. N Pitsikas, et al. Itasetron (DAU 6215) prevents age-related memory deficits in the rat in a multiple choice avoidance task. Eur J Pharmacol. 1996 Sep 12;311(2-3):115-9. [Content Brief]
- [2]. L Patoia, et al. Intravenous itasetron: establishing the effective dose range for the prophylactic control of acute emesis in cancer patients undergoing high-dose cisplatin chemotherapy. Clin Oncol (R Coll Radiol). 1999;11(2):99-104. [Content Brief]
