1234694-22-4
1234694-22-4
Chemical Structure
(−)-C75
- CAS No.: 1234694-22-4
- Formula:C14H22O4
- Molecular Weight:254.32
IUPAC Name: (2S,3R)-4-methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid
InChIKey: VCWLZDVWHQVAJU-NWDGAFQWSA-N
SMILES: CCCCCCCC[C@@H]([C@@H](C1=C)C(O)=O)OC1=O
Biological Activity: ( )-C75 is a isoform of C75 (HY-12364), which is a synthetic fatty-acid synthase (FASN) inhibitor; inhibits prostate cancer cells PC3 with an IC50 of 35 μM[1][2][3]. C75 is a potent CPT1A activator[5].
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(−)-C75 | ( )-C75 is a isoform of C75 (HY-12364), which is a synthetic fatty-acid synthase (FASN) inhibitor; inhibits prostate cancer cells PC3 with an IC50 of 35 μM. C75 is a potent CPT1A activator. | |||||||||||||||||||||
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References
- [1]. Yan Xue, et al. Inhibition of Carnitine Palmitoyltransferase 1A Aggravates Fatty Liver Graft Injury via Promoting Mitochondrial Permeability Transition. Transplantation. 2021 Mar 1;105(3):550-560. [Content Brief]
- [2]. Rae C, et al. Inhibition of Fatty Acid Synthase Sensitizes Prostate Cancer Cells to Radiotherapy. [Content Brief]
- [3]. Makowski K, et al. Differential pharmacologic properties of the two C75 enantiomers: (+)-C75 is a strong anorectic drug; (-)-C75 has antitumor activity. Chirality. 2013 May;25(5):281-7. [Content Brief]
- [5]. Thupari JN, et al. C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9498-502. [Content Brief]
Keywords
