1239468-48-4
Chemical Structure
NCDM-32B
- No. CAS: 1239468-48-4
- Formula:C15H30N2O4
- Molecular Weight:302.41
IUPAC Name: methyl 3-(9-(dimethylamino)-N-hydroxynonanamido)propanoate
InChIKey: KDYRPQNFCURCQB-UHFFFAOYSA-N
SMILES: O=C(CCN(O)C(CCCCCCCCN(C)C)=O)OC
Biological Activity: NCDM-32B is a potent and selective KDM4 inhibitor, with IC50 values of 3.0 μM for KDM4A and 1.0 μM for KDM4C in in vitro enzyme assays. NCDM-32B specifically increases global H3K9me3/me2 levels in basal breast cancer cells. NCDM-32B impairs the viability of KDM4C-amplified basal breast cancer cell lines (HCC1954 and Colo824). NCDM-32B can be used for the study of breast cancer[1][2].
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NCDM-32B | 97.0% | NCDM-32B is a potent and selective KDM4 inhibitor, with IC50 values of 3.0 μM for KDM4A and 1.0 μM for KDM4C in in vitro enzyme assays. NCDM-32B specifically increases global H3K9me3/me2 levels in basal breast cancer cells. NCDM-32B impairs the viability of KDM4C-amplified basal breast cancer cell lines (HCC1954 and Colo824). NCDM-32B can be used for the study of breast cancer. | ||||||||||||||||||||
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Keywords
