1246470-32-5
Chemical Structure
MK-4882
- CAS No.: 1246470-32-5
- Formula:C42H50N8O7
- Molecular Weight:778.90
IUPAC Name: methyl ((S)-1-((S)-2-(5-(4-(5-(2-((S)-1-((methoxycarbonyl)-L-valyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)benzofuran-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate
InChIKey: QKFUCROVTLGTAV-VOIOCNMVSA-N
SMILES: O=C(N[C@@H](C(C)C)C(N1[C@@H](CCC1)C2=NC=C(N2)C3=CC=C(C=C3)C4=CC5=CC(C6=CN=C(N6)[C@H]7N(CCC7)C([C@H](C(C)C)NC(OC)=O)=O)=CC=C5O4)=O)OC
Biological Activity: MK-4882 is an HCV NS5A inhibitor with activity in reducing viral load in a chimpanzee model of HCV infection, but with issues of viral breakthrough, prompting the development of compounds with greater potency against more genotypes and NS5A resistance mutations.
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MK-4882 | MK-4882 is an HCV NS5A inhibitor with activity in reducing viral load in a chimpanzee model of HCV infection, but with issues of viral breakthrough, prompting the development of compounds with greater potency against more genotypes and NS5A resistance mutations. | |||||||||||||||||||||
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Keywords
