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Cat. No.: HY-123649

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MK-4882

MK-4882 is an HCV NS5A inhibitor with activity in reducing viral load in a chimpanzee model of HCV infection, but with issues of viral breakthrough, prompting the development of compounds with greater potency against more genotypes and NS5A resistance mutations.

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CAS No.: 1246470-32-5
Formule: C₄₂H₅₀N₈O₇
Masse moléculaire:778.90

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

MK-4882 Chemical Structure

CAS No.: 1246470-32-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	CC₅₀	7 μM Compound: MK-4882	Cytotoxicity in human HuH7 replicon cells by MTS assay Cytotoxicity in human HuH7 replicon cells by MTS assay	[PMID: 29653894]

Chemical Information

CAS No. 1246470-32-5
Masse moléculaire 778.90
Formule C₄₂H₅₀N₈O₇
SMILES

O=C(N[C@@H](C(C)C)C(N1[C@@H](CCC1)C2=NC=C(N2)C3=CC=C(C=C3)C4=CC5=CC(C6=CN=C(N6)[C@H]7N(CCC7)C([C@H](C(C)C)NC(OC)=O)=O)=CC=C5O4)=O)OC
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Discovery of potent macrocyclic HCV NS5A inhibitors [Content Brief]

[2]. Discovery of MK-8742: an HCV NS5A inhibitor with broad genotype activity

[3]. Discovery and development of hepatitis C virus NS5A replication complex inhibitors

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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