124824-06-2
Chemical Structure
Calphostin B
- CAS No.: 124824-06-2
- Formula:C37H34O11
- Molecular Weight:654.66
InChIKey: IZICYUQZQTUFLF-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CC=C1)OC(CC2=C(C(C3=C(C=C(C(C4=C5C6=C(O)C=C4OC)=C3C2=C5C(CC(C)O)=C(OC)C6=O)OC)O)=O)OC)C
Biological Activity: Calphostin B is a protein kinase C (PKC) inhibitor with an IC50 of 1.04 μM in rats and an IC50 of 22.9 μM for bovine cyclic adenosine monophosphate-dependent protein kinase (PKA). Calphostin B bears aromatic structures at positions C-14 and C-17, which accounts for its higher selectivity for PKC over PKA. Calphostin B can be used in studies related to human cervical cancer and human breast cancer[1].
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Calphostin B | Calphostin B is a protein kinase C (PKC) inhibitor with an IC50 of 1.04 μM in rats and an IC50 of 22.9 μM for bovine cyclic adenosine monophosphate-dependent protein kinase (PKA). Calphostin B bears aromatic structures at positions C-14 and C-17, which accounts for its higher selectivity for PKC over PKA. Calphostin B can be used in studies related to human cervical cancer and human breast cancer. | |||||||||||||||||||||
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Keywords
