Calphostin B
Calphostin B is a protein kinase C (PKC) inhibitor with an IC50 of 1.04 μM in rats and an IC50 of 22.9 μM for bovine cyclic adenosine monophosphate-dependent protein kinase (PKA). Calphostin B bears aromatic structures at positions C-14 and C-17, which accounts for its higher selectivity for PKC over PKA. Calphostin B can be used in studies related to human cervical cancer and human breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 124824-06-2
- Formula: C37H34O11
- Molecular Weight:654.66
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PKC 1.04 μM (IC50) |
PKA 22.9 μM (IC50) |
Calphostin B inhibits partially purified rat brain PKC with an IC50 of 1.04 μM and partially purified bovine heart PKA with an IC50 of 22.9 μM[1].
Calphostin B (1 h) inhibits the growth of human cervical cancer HeLa S3 cells with an IC50 of 2.56 μM and human breast cancer MCF-7 cells with an IC50 of 1.61 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 124824-06-2
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Molecular Weight 654.66
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Formula C37H34O11
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SMILES
O=C(C1=CC=CC=C1)OC(CC2=C(C(C3=C(C=C(C(C4=C5C6=C(O)C=C4OC)=C3C2=C5C(CC(C)O)=C(OC)C6=O)OC)O)=O)OC)C
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Structure Classification
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Initial Source
Cladosporium cladosporioides
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Calphostin B Related Classifications
HY-N19702 Related Classifications
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