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Art. -Nr.: HY-N19702

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Calphostin B

Calphostin B is a protein kinase C (PKC) inhibitor with an IC₅₀ of 1.04 μM in rats and an IC₅₀ of 22.9 μM for bovine cyclic adenosine monophosphate-dependent protein kinase (PKA). Calphostin B bears aromatic structures at positions C-14 and C-17, which accounts for its higher selectivity for PKC over PKA. Calphostin B can be used in studies related to human cervical cancer and human breast cancer.

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CAS. Nr.: 124824-06-2
Formel: C₃₇H₃₄O₁₁
Molecular Weight:654.66

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Calphostin B Chemical Structure

CAS. Nr.: 124824-06-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

PKC

1.04 μM (IC₅₀)

PKA

22.9 μM (IC₅₀)

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In Vitro

Calphostin B inhibits partially purified rat brain PKC with an IC₅₀ of 1.04 μM and partially purified bovine heart PKA with an IC₅₀ of 22.9 μM^[1].
Calphostin B (1 h) inhibits the growth of human cervical cancer HeLa S₃ cells with an IC₅₀ of 2.56 μM and human breast cancer MCF-7 cells with an IC₅₀ of 1.61 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 124824-06-2
Molecular Weight 654.66
Formel C₃₇H₃₄O₁₁
SMILES

O=C(C1=CC=CC=C1)OC(CC2=C(C(C3=C(C=C(C(C4=C5C6=C(O)C=C4OC)=C3C2=C5C(CC(C)O)=C(OC)C6=O)OC)O)=O)OC)C
Structure Classification
- Phenols
- Polyphenols
Initial Source
- Microorganisms
Cladosporium cladosporioides
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Kobayashi E, et al. Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo). 1989 Oct;42(10):1470-4. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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Calphostin B

Alle PKC Isoform-spezifische Produkte anzeigen

Alle PKA Isoform-spezifische Produkte anzeigen