126-07-8
Chemical Structure
Griseofulvin
- CAS. Nr.: 126-07-8
- Formula:C17H17ClO6
- Molecular Weight:352.77
IUPAC Name: (2S,6'R)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H-spiro[benzofuran-2,1'-cyclohexan]-2'-ene-3,4'-dione
InChIKey: DDUHZTYCFQRHIY-RBHXEPJQSA-N
SMILES: O=C1[C@]2(C(OC)=CC(C[C@H]2C)=O)OC3=C(Cl)C(OC)=CC(OC)=C13
Biological Activity: Griseofulvin is an orally active antifungal antibiotic with antitumor activity. Griseofulvin induces apoptosis and G2/M cell cycle arrest in cancer cells. Griseofulvin also has cardiovascular modulatory activity, reducing angina pectoris, relieving hand artery spasm associated with onychomycosis, and peripheral vascular diseases such as shoulder-hand syndrome[1][2][3][4][5][6].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Griseofulvin | 99.07% | Griseofulvin is an orally active antifungal antibiotic with antitumor activity. Griseofulvin induces apoptosis and G2/M cell cycle arrest in cancer cells. Griseofulvin also has cardiovascular modulatory activity, reducing angina pectoris, relieving hand artery spasm associated with onychomycosis, and peripheral vascular diseases such as shoulder-hand syndrome. | ||||||||||||||||||||
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Griseofulvin (Standard) | 98.85% | Griseofulvin (Standard) is the analytical standard of Griseofulvin. This product is intended for research and analytical applications. | ||||||||||||||||||||
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Griseofulvin-13C,d3 | Griseofulvin-13C,d3 is the 13C- and deuterium labeled Griseofulvin. | |||||||||||||||||||||
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Griseofulvin-d3 | Griseofulvin-d3 is the deuterium labeled Griseofulvin. Griseofulvin (Gris-PEG) is a spirocyclic fungal natural product used in treatment of fungal dermatophytes; Antifungal agent. | |||||||||||||||||||||
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- [1]. Brilhante RSN, et al. In vitro activity of azole derivatives and griseofulvin against planktonic and biofilm growth of clinical isolates of dermatophytes. Mycoses. 2018 Jul;61(7):449-454. [Content Brief]
- [2]. Schmeel LC, et al. Griseofulvin Efficiently Induces Apoptosis in In Vitro Treatment of Lymphoma and Multiple Myeloma. Anticancer Res. 2017 May;37(5):2289-2295. [Content Brief]
- [3]. Knasmüller S, et al. Toxic effects of griseofulvin: disease models, mechanisms, and risk assessment[J]. Critical reviews in toxicology, 1997, 27(5): 495-537. [Content Brief]
- [4]. BEDFORD C, et al. Studies on the biological disposition of griseofulvin, an oral antifungal agent[J]. AMA Archives of Dermatology, 1960, 81(5): 735-745. [Content Brief]
- [5]. Aldinger E E. Cardiovascular effects of griseofulvin[J]. Circulation Research, 1968, 22(5): 589-593. [Content Brief]
- [6]. Ho Y S, et al. Griseofulvin potentiates antitumorigenesis effects of nocodazole through induction of apoptosis and G2/M cell cycle arrest in human colorectal cancer cells[J]. International journal of cancer, 2001, 91(3): 393-401. [Content Brief]
