1260-04-4
Chemical Structure
Polygalic acid
- CAS No.: 1260-04-4
- Formula:C29H44O6
- Molecular Weight:488.66
IUPAC Name: (2S,3R,4S,4aR,6aR,8aS,12aS,14aR,14bR)-2,3-dihydroxy-4,6a,11,11,14b-pentamethyl-2,3,4,4a,5,6,6a,7,8,9,10,11,12,12a,13,14,14a,14b-octadecahydropicene-4,8a(1H)-dicarboxylic acid
InChIKey: VZRKWGPIZJDNHC-ZLBVQBNPSA-N
SMILES: C[C@@]1(C(O)=O)[C@@H](O)[C@@H](O)C[C@]2(C)[C@@]3([H])CCC4=C(CC[C@@]5(CCC(C)(C[C@]54[H])C)C(O)=O)[C@@](C)3CC[C@@]12[H]
Biological Activity: Polygalic acid is a polyphenolic acid with neuroprotective effects, and also an inhibitor of African swine fever virus polymerase (AsfvPolX), with an IC50 value of 5.05 μM. Polygalic acid alleviates neuroinflammation by regulating cholinergic activity, and its fecal level decreases in diseased mice. Polygalic acid can be used in research related to painful diabetic peripheral neuropathy complicated with cognitive impairment and African swine fever[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Polygalic acid | 99.96% | Polygalic acid is a polyphenolic acid with neuroprotective effects, and also an inhibitor of African swine fever virus polymerase (AsfvPolX), with an IC50 value of 5.05 μM. Polygalic acid alleviates neuroinflammation by regulating cholinergic activity, and its fecal level decreases in diseased mice. Polygalic acid can be used in research related to painful diabetic peripheral neuropathy complicated with cognitive impairment and African swine fever. | ||||||||||||||||||||
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Polygalic acid (Standard) | ≥98% | Polygalic acid (Standard) is the analytical standard of Polygalic acid. This product is intended for research and analytical applications. Polygalic acid, a triterpenoid saponin, is considered one of the major active constituents of Polygala tenuifolia. | ||||||||||||||||||||
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- [1]. Yang J, et al. Gut microbiota and its metabolites promote painful diabetic peripheral neuropathy complicated with cognitive dysfunction in mice. Front Cell Infect Microbiol. 2025;15:1599954. Published 2025 Sep 2. [Content Brief]
- [2]. Choi J, et al. Polygalic acid inhibits african swine fever virus polymerase activity: findings from machine learning and in vitro testing. J Comput Aided Mol Des. 2023;37(9):453-461. [Content Brief]
