12656-09-6
Chemical Structure
Siomycin A
- CAS No.: 12656-09-6
- Formula:C71H81N19O18S5
- Molecular Weight:1648.84
InChIKey: AKFVOKPQHFBYCA-WAHIHXRRSA-N
SMILES: O=C1N[C@]23[C@@](N=C(C4=NC(C(NC(C(NC(C(N)=O)=C)=O)=C)=O)=CS4)CC3)([H])C5=CSC([C@@]([C@H](OC(C6=CC([C@@H](O)C)=C7C([C@](O)([H])[C@@H](C=C7)N[C@](C(C)C)([H])C(NC(C(NC(C(N[C@H]1C)=O)=C)=O)=C)=O)=N6)=O)C)([H])NC(C8=CSC([C@](NC([C@]9([H])N=C(SC9)/C(NC(C([C@H](O)C)NC(C%10=CSC2=N%10)=O)=O)=C/C)=O)([H])[C@](C)(O)[C@H](O)C)=N8)=O)=N5
Biological Activity: Siomycin A is a thiopeptide antibiotic and is a Forkhead box M1(FOXM1) selective inhibitor without affecting other members of the Forkhead box family. Siomycin A has anti-tumor and promotes apoptosis[1][2].
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Siomycin A | Siomycin A is a thiopeptide antibiotic and is a Forkhead box M1(FOXM1) selective inhibitor without affecting other members of the Forkhead box family. Siomycin A has anti-tumor and promotes apoptosis. | |||||||||||||||||||||
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References
- [1]. Wang B, et al. Effects and mechanism of siomycin A on the growth and apoptosis of MiaPaCa-2 cancer cells. Oncol Lett. 2019 Sep;18(3):2869-2876. [Content Brief]
- [2]. Kim H, et al. Forkhead box M1 (FOXM1) transcription factor is a key oncogenic driver of aggressive human meningioma progression. Neuropathol Appl Neurobiol. 2019 Jun 9. [Content Brief]
