1268273-85-3
Chemical Structure
HSP70-IN-9
- CAS No.: 1268273-85-3
- Formula:C23H26N6OS
- Molecular Weight:434.56
InChIKey: PRPJPXKHEXEWMD-UHFFFAOYSA-N
SMILES: O=C(CN)NC1=CC(SC2=CN=C(N3CCN(CC3)C)N=C2C4=CC=CC=C4)=CC=C1
Biological Activity: HSP70-IN-9 is an Hsp70 inhibitor that induces caspase-3,7 activation with an IC50 of 25.2 μM. HSP70-IN-9 reversibly binds to the allosteric pocket of the N-terminal domain, disrupts the Hsp70-HOP-Hsp90 mega-complex, and inhibits client protein refolding, thereby inducing apoptosis and degradation of Hsp90-Hsp70 tumor client proteins, ultimately inhibiting cancer cell growth. HSP70-IN-9 can be used for research on breast cancer, pancreatic cancer, and acute myeloid leukemia[1].
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HSP70-IN-9 | HSP70-IN-9 is an Hsp70 inhibitor that induces caspase-3,7 activation with an IC50 of 25.2 μM. HSP70-IN-9 reversibly binds to the allosteric pocket of the N-terminal domain, disrupts the Hsp70-HOP-Hsp90 mega-complex, and inhibits client protein refolding, thereby inducing apoptosis and degradation of Hsp90-Hsp70 tumor client proteins, ultimately inhibiting cancer cell growth. HSP70-IN-9 can be used for research on breast cancer, pancreatic cancer, and acute myeloid leukemia. | |||||||||||||||||||||
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References
- [1]. Taldone T, et al. Heat shock protein 70 inhibitors. 2. 2,5'-thiodipyrimidines, 5-(phenylthio)pyrimidines, 2-(pyridin-3-ylthio)pyrimidines, and 3-(phenylthio)pyridines as reversible binders to an allosteric site on heat shock protein 70. Journal of medicinal chemistry. 2014 Feb 27;57(4):1208-24. [Content Brief]
