1269802-68-7
Chemical Structure
LDHA-IN-1
- CAS No.: 1269802-68-7
- Formula:C16H10F3NO3
- Molecular Weight:321.26
IUPAC Name: 1-hydroxy-6-phenyl-4-(trifluoromethyl)-1H-indole-2-carboxylic acid
InChIKey: KGXDBNBXAPVUIM-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC=2C(=CC(=CC2C(F)(F)F)C=3C=CC=CC3)N1O
Biological Activity: LDHA-IN-1 is a selective, competitive LDH-A inhibitor, with Ki values of 8.9 μM (NADH assay) and 4.7 μM (Pyruvate assay) against hLDH-A. LDHA-IN-1 inhibits cancer cell proliferation under hypoxic conditions. LDHA-IN-1 can be used in the research of ovarian cancer, colorectal cancer, mesothelioma and pancreatic cancer[1].
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LDHA-IN-1 | LDHA-IN-1 is a selective, competitive LDH-A inhibitor, with Ki values of 8.9 μM (NADH assay) and 4.7 μM (Pyruvate assay) against hLDH-A. LDHA-IN-1 inhibits cancer cell proliferation under hypoxic conditions. LDHA-IN-1 can be used in the research of ovarian cancer, colorectal cancer, mesothelioma and pancreatic cancer. | |||||||||||||||||||||
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Keywords
