1270966-08-9
Chemical Structure
Thiobenzanilide 63T
- CAS No.: 1270966-08-9
- Formula:C20H10F6N2S2
- Molecular Weight:456.43
IUPAC Name: N,N'-(1,2-phenylene)bis(3,4,5-trifluorobenzothioamide)
InChIKey: FTBUGAOZORHTKF-UHFFFAOYSA-N
SMILES: FC1=C(F)C(F)=CC(C(NC2=C(NC(C3=CC(F)=C(C(F)=C3)F)=S)C=CC=C2)=S)=C1
Biological Activity: Thiobenzanilide 63T (63T) is a small molecule that selectively induces cancer cell death in a caspase-independent pathway. Thiobenzanilide 63T induces reactive oxygen species and lipid peroxidation. Thiobenzanilide 63T demonstrates strong cytotoxic activity against a lung-derived cancer cell line. Thiobenzanilide 63T decreases the expression of heme oxygenase (HO-1) in A549 cells[1][2].
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Thiobenzanilide 63T | Thiobenzanilide 63T (63T) is a small molecule that selectively induces cancer cell death in a caspase-independent pathway. Thiobenzanilide 63T induces reactive oxygen species and lipid peroxidation. Thiobenzanilide 63T demonstrates strong cytotoxic activity against a lung-derived cancer cell line. Thiobenzanilide 63T decreases the expression of heme oxygenase (HO-1) in A549 cells. | |||||||||||||||||||||
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- [1]. Kucinska M, et al. Selective anticancer activity of the novel thiobenzanilide 63T against human lung adenocarcinoma cells. Toxicol In Vitro. 2016 Dec;37:148-161. [Content Brief]
- [2]. Kucinska M, et al. The role of oxidative stress in 63 T-induced cytotoxicity against human lung cancer and normal lung fibroblast cell lines. Invest New Drugs. 2019 Oct;37(5):849-864. [Content Brief]
Keywords
