127266-56-2
127266-56-2
Chemical Structure
Adatanserin
Synonym(s): WY-50324; SEB-324
- CAS No.: 127266-56-2
- Formula:C21H31N5O
- Molecular Weight:369.50
IUPAC Name: N-(2-(4-(pyrimidin-2-yl)piperazin-1-yl)ethyl)adamantane-1-carboxamide
InChIKey: HPFLVTSWRFCPCV-UHFFFAOYSA-N
SMILES: O=C(NCCN1CCN(CC1)C2=NC=CC=N2)C34CC(CC(C4)C5)CC5C3
Biological Activity: Adatanserin (WY-50324) is a high affinity, selective and partial agonist for the 5-HT1A receptor with a Ki of 1 nM. Adatanserin is a moderate affinity 5-HT2 receptor antagonist with a Ki of 73 nM. Adatanserin shows significant anxiolytic and antidepressant activity in an animal conflict model[1][2].
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Adatanserin | Adatanserin (WY-50324) is a high affinity, selective and partial agonist for the 5-HT1A receptor with a Ki of 1 nM. Adatanserin is a moderate affinity 5-HT2 receptor antagonist with a Ki of 73 nM. Adatanserin shows significant anxiolytic and antidepressant activity in an animal conflict model. | |||||||||||||||||||||
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References
- [1]. M A Abou-Gharbia, et al. Synthesis and SAR of adatanserin: novel adamantyl aryl- and heteroarylpiperazines with dual serotonin 5-HT(1A) and 5-HT(2) activity as potential anxiolytic and antidepressant agents. [Content Brief]
- [2]. A Singh, et al. Antidepressant-like activity of compounds with varying efficacy at 5-HT1A receptors. Neuropharmacology. 1993 Apr;32(4):331-40. [Content Brief]
