127500-84-9
Chemical Structure
Ro 41-1049
- CAS No.: 127500-84-9
- Formula:C12H12FN3OS
- Molecular Weight:265.31
IUPAC Name: N-(2-aminoethyl)-5-(3-fluorophenyl)thiazole-4-carboxamide
InChIKey: SCKBPXUWGMKLDM-UHFFFAOYSA-N
SMILES: O=C(NCCN)C=1N=CSC1C=2C=CC=C(F)C2
Biological Activity: Ro 41-1049 is a highly selective, reversible MAO-A inhibitor. Ro 41-1049 effectively blocks the Quinpirole (HY-B1752)-induced increase in dopamine D2-like receptor density in the nucleus accumbens and alters the pattern of behavioral sensitization, shifting animals' responses from enhanced motor activity to immobile self-directed gaping behavior. Tritium-labeled Ro 41-1049 serves as a high-affinity radioligand, enabling accurate mapping of the distribution and abundance of MAO-A in the central nervous system, peripheral organs, and human brain via quantitative enzyme autoradiography. Ro 41-1049 can be used for basic research on depression and other related diseases[1][2][3].
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Ro 41-1049 | Ro 41-1049 is a highly selective, reversible MAO-A inhibitor. Ro 41-1049 effectively blocks the Quinpirole (HY-B1752)-induced increase in dopamine D2-like receptor density in the nucleus accumbens and alters the pattern of behavioral sensitization, shifting animals' responses from enhanced motor activity to immobile self-directed gaping behavior. Tritium-labeled Ro 41-1049 serves as a high-affinity radioligand, enabling accurate mapping of the distribution and abundance of MAO-A in the central nervous system, peripheral organs, and human brain via quantitative enzyme autoradiography. Ro 41-1049 can be used for basic research on depression and other related diseases. | |||||||||||||||||||||
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References
- [1]. Culver KE, et al.. Altered dopamine D2-like receptor binding in rats with behavioral sensitization to quinpirole: effects of pre-treatment with Ro 41-1049. European journal of pharmacology. 2008 Sep 11;592(1-3):67-72. [Content Brief]
- [2]. Saura J, et al. Quantitative enzyme radioautography with 3H-Ro 41-1049 and 3H-Ro 19-6327 in vitro: localization and abundance of MAO-A and MAO-B in rat CNS, peripheral organs, and human brain[J]. Journal of Neuroscience, 1992, 12(5): 1977-1999.
- [3]. Da Prada M, et al. From moclobemide to Ro 19-6327 and Ro 41-1049: the development of a new class of reversible, selective MAO-A and MAO-B inhibitors[C]//Neurotransmitter Actions and Interactions: Proceedings of a Satellite Symposium of the 12th International Society for Neurochemistry Meeting, Algarve, Portugal, April 29–30, 1989. Vienna: Springer Vienna, 1990: 279-292.
