1280725-80-5
Chemical Structure
X-370
- CAS No.: 1280725-80-5
- Formula:C27H31F2N9O2
- Molecular Weight:551.59
IUPAC Name: (4-(6-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-2-morpholino-9H-purin-9-yl)piperidin-1-yl)(pyrrolidin-1-yl)methanone
InChIKey: VOGPSFXHACOOSK-UHFFFAOYSA-N
SMILES: FC(F)C1=NC2=C(N1C3=NC(N4CCOCC4)=NC5=C3N=CN5C6CCN(C(N7CCCC7)=O)CC6)C=CC=C2
Biological Activity: X-370 is a PI3Kδ inhibitor (IC50 = 7 nM). X-370 inhibits the survival of leukemia cells, inducing G1 arrest and apoptosis. X-370 blocks PDK1 binding and phosphorylation of MEK1/2, eliminating Akt and Erk1/2 signaling. X-370 can be used in research on B-cell acute lymphoblastic leukemia (B-ALL)[1].
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X-370 | X-370 is a PI3Kδ inhibitor (IC50 = 7 nM). X-370 inhibits the survival of leukemia cells, inducing G1 arrest and apoptosis. X-370 blocks PDK1 binding and phosphorylation of MEK1/2, eliminating Akt and Erk1/2 signaling. X-370 can be used in research on B-cell acute lymphoblastic leukemia (B-ALL). | |||||||||||||||||||||
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Keywords
