128201-92-3
Chemical Structure
IST-622
Synonym(s): 6-O-(3-Ethoxypropionyl)-3',4'-O-exo-benzylidenechartreusin
- CAS No.: 128201-92-3
- Formula:C44H44O16
- Molecular Weight:828.81
InChIKey: YAZCVTSUQIJVMZ-SDMTUEQXSA-N
SMILES: CCOCCC(OC1=C(C=CC=C2O[C@H]3[C@@H]([C@]4([H])[C@](O[C@H](C5=CC=CC=C5)O4)([H])[C@H](O3)C)O[C@@H]6[C@@H]([C@H]([C@H]([C@H](O6)C)O)OC)O)C2=C(OC(C7=C(C)C=CC(O8)=C79)=O)C9=C1C8=O)=O
Biological Activity: IST-622 (6-O-(3-Ethoxypropionyl)-3',4'-O-exo-benzylidenechartreusin) is an anti-tumor agent with significant growth inhibitory activity. IST-622 exhibits significant anti-tumor effects against a variety of mouse tumors such as P388 and L1210 leukemias, B16 melanoma, Lewis lung carcinoma, Colon 26 and Colon 38 adenocarcinomas, and M5076 reticulum cell sarcoma. IST-622 was orally administered and the results showed efficacy in different tumor types. In addition, IST-622 provided significant inhibitory effects against two human tumor xenograft models: large cell lung carcinoma (Lu-116) and gastric adenocarcinoma (St-4). IST-622 also exhibited significant growth inhibitory activity against P388 leukemia in vitro, with a half inhibitory concentration (IC50) more than 20 times lower than CT[1].
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IST-622 | IST-622 (6-O-(3-Ethoxypropionyl)-3',4'-O-exo-benzylidenechartreusin) is an anti-tumor agent with significant growth inhibitory activity. IST-622 exhibits significant anti-tumor effects against a variety of mouse tumors such as P388 and L1210 leukemias, B16 melanoma, Lewis lung carcinoma, Colon 26 and Colon 38 adenocarcinomas, and M5076 reticulum cell sarcoma. IST-622 was orally administered and the results showed efficacy in different tumor types. In addition, IST-622 provided significant inhibitory effects against two human tumor xenograft models: large cell lung carcinoma (Lu-116) and gastric adenocarcinoma (St-4). IST-622 also exhibited significant growth inhibitory activity against P388 leukemia in vitro, with a half inhibitory concentration (IC50) more than 20 times lower than CT. | |||||||||||||||||||||
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