128232-14-4
Chemical Structure
Raxofelast
Synonym(s): IRFI-016
- CAS No.: 128232-14-4
- Formula:C15H18O5
- Molecular Weight:278.30
IUPAC Name: 2-(5-acetoxy-4,6,7-trimethyl-2,3-dihydrobenzofuran-2-yl)acetic acid
InChIKey: QLWBKUUORSULMI-UHFFFAOYSA-N
SMILES: O=C(CC1OC2=C(C1)C(C)=C(OC(C)=O)C(C)=C2C)O
Biological Activity: Raxofelast (IRFI-016) is an antioxidant agent in various models of ischemia-reperfusion injury. Raxofelast has antiproliferative activity in H2O2-stimulated rat aortic smooth muscle cells. Raxofelast attenuates the activation of mitogen-activating protein kinase (MAPK), ERK kinase 1, 2 (MEK1,2) and protein kinase C (PKC) without affecting Ras expression[1].
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Raxofelast | Raxofelast (IRFI-016) is an antioxidant agent in various models of ischemia-reperfusion injury. Raxofelast has antiproliferative activity in H2O2-stimulated rat aortic smooth muscle cells. Raxofelast attenuates the activation of mitogen-activating protein kinase (MAPK), ERK kinase 1, 2 (MEK1,2) and protein kinase C (PKC) without affecting Ras expression. | |||||||||||||||||||||
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Keywords
