129212-35-7
Chemical Structure
Tacrolimus 8-epimer
Synonym(s): Tacrolimus EP impurity D; 8-epi-Tacrolimus
- CAS No.: 129212-35-7
- Formula:C44H69NO12
- Molecular Weight:804.02
IUPAC Name: (1R,2R,4S,5S,7r)-7-(2-hydroxy-2,2-di(thiophen-2-yl)acetoxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-ium bromide
InChIKey: QJJXYPPXXYFBGM-NCGCDJFJSA-N
SMILES: CO[C@@H]1[C@]2([H])O[C@]([C@@H](C1)C)(C(C(N3[C@](CCCC3)([H])C(O[C@@H]([C@@H]([C@H](CC([C@H](/C=C(C[C@@H](C[C@@H]2OC)C)\C)CC=C)=O)O)C)/C(C)=C/[C@H]4C[C@H]([C@@H](CC4)O)OC)=O)=O)=O)O
Biological Activity: Tacrolimus 8-epimer (Tacrolimus EP impurity D) is the C-8 epimer and degradation impurity of Tacrolimus (HY-13756). Tacrolimus 8-epimer forms via base-catalyzed epimerization of Tacrolimus, and also generates under iodine-catalyzed free radical conditions. Tacrolimus 8-epimer is mainly used as a reference substance for impurity analysis, pharmaceutical quality control and stability-related studies of Tacrolimus[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Tacrolimus 8-epimer | 96.64% | Tacrolimus 8-epimer (Tacrolimus EP impurity D) is the C-8 epimer and degradation impurity of Tacrolimus (HY-13756). Tacrolimus 8-epimer forms via base-catalyzed epimerization of Tacrolimus, and also generates under iodine-catalyzed free radical conditions. Tacrolimus 8-epimer is mainly used as a reference substance for impurity analysis, pharmaceutical quality control and stability-related studies of Tacrolimus. | ||||||||||||||||||||
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References
- [1]. Sajjadi S, et al. Stability Tests and Analytical Methods of Tacrolimus: A Review. ImmunoAnalysis. 2022;2:13.
- [2]. Skytte DM, et al. Synthesis and characterization of an epimer of tacrolimus, an immunosuppressive drug. J Nat Prod. 2010;73(4):776-779.
- [3]. Skytte DM, et al. Some transformations of tacrolimus, an immunosuppressive drug. Eur J Pharm Sci. 2013;48(3):514-522.
