129212-35-7

Tacrolimus 8-epimer Chemical Structure
129212-35-7

Chemical Structure

Tacrolimus 8-epimer

Synonym(s): Tacrolimus EP impurity D; 8-epi-Tacrolimus

  • CAS No.: 129212-35-7
  • Formula:C44H69NO12
  • Molecular Weight:804.02

IUPAC Name: (1R,2R,4S,5S,7r)-7-(2-hydroxy-2,2-di(thiophen-2-yl)acetoxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-ium bromide

InChIKey: QJJXYPPXXYFBGM-NCGCDJFJSA-N

SMILES: CO[C@@H]1[C@]2([H])O[C@]([C@@H](C1)C)(C(C(N3[C@](CCCC3)([H])C(O[C@@H]([C@@H]([C@H](CC([C@H](/C=C(C[C@@H](C[C@@H]2OC)C)\C)CC=C)=O)O)C)/C(C)=C/[C@H]4C[C@H]([C@@H](CC4)O)OC)=O)=O)=O)O

Biological Activity: Tacrolimus 8-epimer (Tacrolimus EP impurity D) is the C-8 epimer and degradation impurity of Tacrolimus (HY-13756). Tacrolimus 8-epimer forms via base-catalyzed epimerization of Tacrolimus, and also generates under iodine-catalyzed free radical conditions. Tacrolimus 8-epimer is mainly used as a reference substance for impurity analysis, pharmaceutical quality control and stability-related studies of Tacrolimus[1][2][3].

Cat. No. Product Name Purity Description Pricing
HY-Z8754 		Tacrolimus 8-epimer 96.64% Tacrolimus 8-epimer (Tacrolimus EP impurity D) is the C-8 epimer and degradation impurity of Tacrolimus (HY-13756). Tacrolimus 8-epimer forms via base-catalyzed epimerization of Tacrolimus, and also generates under iodine-catalyzed free radical conditions. Tacrolimus 8-epimer is mainly used as a reference substance for impurity analysis, pharmaceutical quality control and stability-related studies of Tacrolimus.
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