129830-96-2
Chemical Structure
Glycerophosphoinositol 4-phosphate
Synonym(s): GroPIns-4-P
- CAS No.: 129830-96-2
- Formula:C9H20O14P2
- Molecular Weight:414.19
InChIKey: MRHAWIJFXZJZEV-PEDBETPVSA-N
SMILES: O[C@@H]1[C@H]([C@@H]([C@H]([C@@H]([C@@H]1O)OP(OC[C@@H](CO)O)(O)=O)O)O)OP(O)(O)=O
Biological Activity: Glycerophosphoinositol 4-phosphate (GroPIns-4-P) is a metabolite of phospholipase A and an inhibitor of adenylylcyclase. Glycerophosphoinositol 4-phosphate can regulate cAMP-dependent cellular functions. Glycerophosphoinositol 4-phosphate can also induce the formation of membrane ruffles and stress fibers in serum-starved Swiss 3T3 cells by activating the small GTPases Rac and Rho, respectively. Glycerophosphoinositol 4-phosphate can be used in research on cancer cell motility and invasiveness[1][2].
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Glycerophosphoinositol 4-phosphate | Glycerophosphoinositol 4-phosphate (GroPIns-4-P) is a metabolite of phospholipase A and an inhibitor of adenylylcyclase. Glycerophosphoinositol 4-phosphate can regulate cAMP-dependent cellular functions. Glycerophosphoinositol 4-phosphate can also induce the formation of membrane ruffles and stress fibers in serum-starved Swiss 3T3 cells by activating the small GTPases Rac and Rho, respectively. Glycerophosphoinositol 4-phosphate can be used in research on cancer cell motility and invasiveness. | |||||||||||||||||||||
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References
- [1]. Mancini R, et al. Reorganization of actin cytoskeleton by the phosphoinositide metabolite glycerophosphoinositol 4-phosphate. Mol Biol Cell. 2003 Feb;14(2):503-15. [Content Brief]
- [2]. Iacovelli L, et al. Glycerophosphoinositol 4-phosphate, a putative endogenous inhibitor of adenylylcyclase. J Biol Chem. 1993 Sep 25;268(27):20402-7. [Content Brief]
