130116-16-4
130116-16-4
Chemical Structure
CI-986
- CAS No.: 130116-16-4
- Formula:C21H35N3O2S2
- Molecular Weight:425.65
IUPAC Name: 2-hydroxy-N,N,N-trimethylethan-1-aminium 2,6-di-tert-butyl-4-(5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)phenolate
InChIKey: BIZSVVIRPJXFOI-UHFFFAOYSA-M
SMILES: [O-]C1=C(C(C)(C)C)C=C(C2=NNC(S2)=S)C=C1C(C)(C)C.OCC[N+](C)(C)C
Biological Activity: CI-986 is a dual inhibitor of COX and 5-LOX. CI-986 can prevent the coronary vasoconstriction and the increased production of LTB(4) and LTC(4). CI-986 also has anti-inflammatory and analgesic effects. CI-986 can be used for the researches of inflammation and cardiovascular disease, such as arthritis[1][2].
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CI-986 | CI-986 is a dual inhibitor of COX and 5-LOX. CI-986 can prevent the coronary vasoconstriction and the increased production of LTB(4) and LTC(4). CI-986 also has anti-inflammatory and analgesic effects. CI-986 can be used for the researches of inflammation and cardiovascular disease, such as arthritis. | |||||||||||||||||||||
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References
- [1]. Gök S, et al. Role of leukotrienes on coronary vasoconstriction in isolated hearts of arthritic rats: effect of in vivo treatment with CI-986, a dual inhibitor of cyclooxygenase and lipoxygenase. Pharmacology. 2000 Jan;60(1):41-6. [Content Brief]
- [2]. Schrier DJ, et al. The pharmacologic effects of 5-[3,5-bis(1,1-dimethylethyl)-4- hydroxyphenyl]-1,3,4-thiadiazole-2(3H)-thione, choline salt (CI-986), a novel inhibitor of arachidonic acid metabolism in models of inflammation, analgesia and gastric irritation. Prostaglandins. 1994 Jan;47(1):17-30. [Content Brief]
