13074-39-0
13074-39-0
Chemical Structure
Adamantan-2-amine
Synonym(s): 2-Aminoadamantane
- CAS No.: 13074-39-0
- Formula:C10H17N
- Molecular Weight:151.25
IUPAC Name: (1r,3r,5r,7r)-adamantan-2-amine
InChIKey: QZWNXXINFABALM-MGPGSJOLSA-N
SMILES: NC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2
Biological Activity: Adamantan-2-amine (2-Aminoadamantane) serves as the hydrophobic tag structural unit of Tubulin degrader 2 (HY-161641) and is used for the synthesis of anticancer drugs that target tubulin via a dual mechanism. Adamantan-2-amine can be applied in research on breast cancer, lung cancer, colorectal cancer, and Parkinson's syndrome[1][2][3].
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Adamantan-2-amine | Adamantan-2-amine (2-Aminoadamantane) serves as the hydrophobic tag structural unit of Tubulin degrader 2 (HY-161641) and is used for the synthesis of anticancer drugs that target tubulin via a dual mechanism. Adamantan-2-amine can be applied in research on breast cancer, lung cancer, colorectal cancer, and Parkinson's syndrome. | |||||||||||||||||||||
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References
- [1]. Wang S, et al. Design, synthesis and biological evaluation of novel tubulin-targeting agents with a dual-mechanism for polymerization inhibition and protein degradation. European journal of medicinal chemistry. 2024 Jun 05;272:116458. [Content Brief]
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[2]. Morozov IS, et al. Anticataleptic activity of heterocyclic 2-aminoadamantane derivatives. Pharm Chem J. 2000 Apr;34(4):189-192. doi:10.1007/BF02524595.
- [3]. Eisa HM, et al. Synthesis of certain 2-aminoadamantane derivatives as potential antimicrobial agents. Die Pharmazie. 1991 Mar;46(3):182-4.
