130759-56-7
Chemical Structure
Nemazoline
Synonym(s): A-57219 free base; SCH 40054 free base
- CAS No.: 130759-56-7
- Formula:C10H11Cl2N3
- Molecular Weight:244.12
IUPAC Name: 2,6-dichloro-4-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline
InChIKey: FXNNRWAIGIEAST-UHFFFAOYSA-N
SMILES: NC1=C(C=C(C=C1Cl)CC2=NCCN2)Cl
Biological Activity: Nemazoline (A-57219) is selective α-adrenergic agent with α1-agonist/α2-antagonist activity, which is used as a nasal decongestant. Nemazoline produces decongestion by α1-mediated contraction of capacitance vessels, but not compromises blood flow by virtue of α2-antagonism. Nemazoline also blocks endogenous noradrenaline-mediated α 2-constriction of the resistance vessels[1].
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Nemazoline | Nemazoline (A-57219) is selective α-adrenergic agent with α1-agonist/α2-antagonist activity, which is used as a nasal decongestant. Nemazoline produces decongestion by α1-mediated contraction of capacitance vessels, but not compromises blood flow by virtue of α2-antagonism. Nemazoline also blocks endogenous noradrenaline-mediated α 2-constriction of the resistance vessels. | |||||||||||||||||||||
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