13112-05-5
Chemical Structure
P2X2R antagonist-1
- CAS No.: 13112-05-5
- Formula:C23H14N6Na2O10S2
- Molecular Weight:644.50
InChIKey: GVOXJNFFTBQRER-UHFFFAOYSA-L
SMILES: O=C1N=C(NC2=CC(NC(C=C(S(=O)(O[Na])=O)C(N)=C3C(C4=C5C=CC=C4)=O)=C3C5=O)=CC=C2S(=O)(O[Na])=O)NC(N1)=O
Biological Activity: P2X2R antagonist-1 (compound 66) is a P2X2 receptor antagonist derived from Reactive Blue 4 (HY-125815). P2X2R antagonist-1 shows high selectivity for P2X4, P2X7, P2Y2, P2Y4, P2Y6 and P2Y12 receptors, moderate selectivity for P2X1 and P2X3 receptors, and exhibits higher potency toward homomeric P2X2 receptors than heteromeric P2X2/3 receptors. P2X2R antagonist-1 competitively inhibits ATP-mediated currents. P2X2R antagonist-1 can be used in research related to pain and urinary incontinence[1].
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P2X2R antagonist-1 | P2X2R antagonist-1 (compound 66) is a P2X2 receptor antagonist derived from Reactive Blue 4 (HY-125815). P2X2R antagonist-1 shows high selectivity for P2X4, P2X7, P2Y2, P2Y4, P2Y6 and P2Y12 receptors, moderate selectivity for P2X1 and P2X3 receptors, and exhibits higher potency toward homomeric P2X2 receptors than heteromeric P2X2/3 receptors. P2X2R antagonist-1 competitively inhibits ATP-mediated currents. P2X2R antagonist-1 can be used in research related to pain and urinary incontinence. | |||||||||||||||||||||
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Keywords
