1311892-52-0
1311892-52-0
Chemical Structure
ORS-14
- CAS No.: 1311892-52-0
- Formula:C17H17N5O2
- Molecular Weight:323.35
InChIKey: MPHYKMUJVCLQMQ-UHFFFAOYSA-N
SMILES: O=C(NCC1=CC=NC(OC2=CC=C(C)C(C)=C2)=C1)C3=CNN=N3
Biological Activity: ORS-14 is a LILRB4/ILT3 ligand with a Kd of 85.2 nM for human receptors. ORS-14 blocks SCG2-mediated LILRB4 signaling pathway, reverses SCG2-mediated immunosuppression, restores cytokine production, reduces tumor cell viability, recovers cytotoxic T cell function, and increases the frequency of granzyme B+ CD8+ T cells. ORS-14 can be used in research related to colorectal cancer and acute myeloid leukemia[1].
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ORS-14 | ORS-14 is a LILRB4/ILT3 ligand with a Kd of 85.2 nM for human receptors. ORS-14 blocks SCG2-mediated LILRB4 signaling pathway, reverses SCG2-mediated immunosuppression, restores cytokine production, reduces tumor cell viability, recovers cytotoxic T cell function, and increases the frequency of granzyme B+ CD8+ T cells. ORS-14 can be used in research related to colorectal cancer and acute myeloid leukemia. | |||||||||||||||||||||
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