132368-08-2
Chemical Structure
Tripchlorolide
- CAS No.: 132368-08-2
- Formula:C20H25ClO6
- Molecular Weight:396.86
IUPAC Name: (5aS,5bS,6aR,7R,8R,9R,9aS,10aS,11aS)-7-chloro-8,9-dihydroxy-8-isopropyl-5a-methyl-4,5,5a,6a,7,8,9,10a,11,11a-decahydrobis(oxireno)[2',3':4b,5;2'',3'':8a,9]phenanthro[1,2-c]furan-3(1H)-one
InChIKey: OIMACDABKWJVSQ-LZVGCMTRSA-N
SMILES: C[C@@]([C@@]1([H])C2)(CCC3=C1COC3=O)[C@]4([C@@]([C@H]5Cl)([H])O4)[C@]6([C@@H]([C@@](O)5C(C)C)O)[C@@]2([H])O6
Biological Activity: Tripchlorolide is a neuroprotective agent that can be found in Tripterygium wilfordii. Tripchlorolide prevents tumor growth by inducing apoptosis and autophagy. Tripchlorolide improves cognitive deficits in Alzheimer's disease[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Tripchlorolide | 95.68% | Tripchlorolide is a neuroprotective agent that can be found in Tripterygium wilfordii. Tripchlorolide prevents tumor growth by inducing apoptosis and autophagy. Tripchlorolide improves cognitive deficits in Alzheimer's disease. | ||||||||||||||||||||
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- [1]. Li FQ, et, al. Neurotrophic and neuroprotective effects of tripchlorolide, an extract of Chinese herb Tripterygium wilfordii Hook F, on dopaminergic neurons. Exp Neurol. 2003 Jan;179(1):28-37. [Content Brief]
- [2]. Chen L, et, al. Tripchlorolide induces cell death in lung cancer cells by autophagy. Int J Oncol. 2012 Apr;40(4):1066-70. [Content Brief]
- [3]. Zeng Y, et, al. Tripchlorolide improves cognitive deficits by reducing amyloid β and upregulating synapse-related proteins in a transgenic model of Alzheimer's Disease. J Neurochem. 2015 Apr;133(1):38-52. [Content Brief]
Keywords
